Novartis study shows skin cancer combo also works

新闻来源:http://www.reuters.com/article/us-health-cancer-novartis-idUSKCN0YS1MI

A Novartis trial of two drugs against an aggressive lung cancer bodes well for broadening their use beyond melanoma, the Swiss drugmaker told the American Society of Clinical Oncology's conference in Chicago on Tuesday.

Novartis's Tafinlar and Mekinist combination shrank tumors in 63 percent of the trial's 57 people with BRAF V600E-mutation positive non-small cell lung cancer who had failed on chemotherapy, the company said, citing a Phase II study.

The company already has U.S. Food and Drug Administration and European approvals for the drugs against BRAF V600E-mutation positive melanoma.

It is now aiming for a U.S. regulatory submission for lung cancer after July, Alessandro Riva, global head of Novartis Oncology Development, said in an interview.

Rare-but-deadly BRAF V600E-mutation positive lung cancer is marked by a gene change that helps it grow, making fighting it difficult with chemotherapy. In the study, the median progression-free survival was 9.7 months, which Riva called unprecedented. The latest findings follow those from an interim analysis of 24 patients in 2015 that showed similar results.

"We are talking about a response rate that is in the 60 percent ballpark, (with) progression-free survival that is approaching 10 months -- never seen in the past with chemotherapy", Riva said. "Chemotherapy... has a progression-free survival (PFS) that is not more than two or three months." The median analyst estimate for 2018 sales for both drugs is about $1.3 billion, according to Reuters data.